Psychoactive Medications

Candidates must stop taking all psychoactive medications (such as amitriptyline, Elavil, Prozac, Zoloft, Paxil) for a minimum of five days prior to Ibogaine treatment. Ibogaine is known to interact and increase the effects of some drugs. For this reason Ibogaine must not be taken until we can be sure that certain types of drugs, especially antidepressants, antipsychotics, amphetamines, and other prescription medications or illicit drugs, are cleared out of your system.


Fentanyl use must be suspended 2 weeks prior to treatment and preferably the patient switch over to a short-acting opiate such as hydrocodone or oxycodone. Ibogaine treatment directly after fentanyl use has been shown to cause arrhythmias.

Suboxone/Subutex (Buprenorphine)

Regarding these replacement therapies, we have seen success with a minimum of 7 days suspension (3 weeks is ideal but not always possible or advisable) but often this requires boosters for several weeks, which we can accommodate.


Methadone use must be suspended minimum 10 days prior to treatment and ideally 2-3 weeks to ensure best results with Ibogaine and no post-acute withdrawal symptoms. Switching over to a short-acting opiate is also advisable for controlling withdrawals during this time.

Other Medications

Other medications that should not be combined with Ibogaine include omeprazol (Losec), anti-fungal medications (Diflucan), clarityne, and macrolide type antibiotics (Azithromycin, Zithromax). All of these need to be suspended at least 5 days before Ibogaine treatment.

Risk of Exclusion from the program

Given the potential for serious adverse drug interaction with Ibogaine as well as problems that can occur when Ibogaine is given to people with the medical conditions outlined above, the medical staff at Ibogaine University reserves the right to exclude candidates from further consideration on the basis of failing to completely or honestly report all information sought by staff at Ibogaine University and provided by the patient. This, of course, is for your safety.

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